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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Nat Struct Mol Biol. 2023 Feb 6;30(3):391–402. doi: 10.1038/s41594-023-00921-z

Extended Data Fig. 10. Filament formation in PRPS1 disease mutants.

Extended Data Fig. 10

A. Kinetic parameters for the wild type protein and the four disease mutations as determined from the data shown in Main Text Figure 6. B. Chromatography curves from a Superose 6 of PRPS1 and four disease mutations. C. Panel of negative stain EM sections of PRPS1 disease mutations in phosphate buffer in the presence of the indicated ligands.