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. 2022 Sep 27;93(4):905–910. doi: 10.1038/s41390-022-02313-3

Fig. 1. Genome sequencing (GS) for pharmacogenetic (PGx) profiling in children with medical complexity (CMC).

Fig. 1

a Overview of study design and key findings related to currently prescribed medications (Rxs) in a large cohort of CMC. b Number of CMC taking medications in each drug category. See main text for details. The cancer drug category (n = 3 CMC; Supplementary Table S4) is not shown. c Number of CMC with diplotypes affecting metabolism, for each interrogated pharmacogene. See main text for details. The high proportion with PGx variants in CYP3A5, VKORC1, and CYP2C19 is consistent with CPIC®-reported frequencies in the general population. d Metabolizer status phenotypes for CYP2C1.