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. 2023 Mar 16;29(3):593–604. doi: 10.1038/s41591-022-02189-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Forest plot of the odds ratio (95% confidence interval) to explore the association between treatment arm and MPR for each subgroup (Nivo+CT, n = 22; Ipi+Nivo+CT, n = 22). b, Forest plot of the odds ratio (95% confidence interval) to explore the association between treatment arm (Nivo+CT, n = 17; Ipi+Nivo+CT, n = 16) and MPR for each subgroup in patients without known tumor EGFR/ALK alterations. In both panels, the vertical reference lines at 1 indicate no difference between two treatment arms. The point estimates of odds ratios are represented by solid squares. The whiskers are the two lines that extend to the lower and upper bounds of the 95% confidence intervals. The lower and upper limits of the 95% confidence intervals are clipped at 0.1 and 10.0 to arrows. The odds ratios and 95% confidence interval are from univariate logistic regression. MPR, major pathologic response; Nivo, nivolumab; Ipi, ipilimumab; CT, chemotherapy; Never, never smoker; Former/Current, former/current smoker; ECOG, Eastern Cooperative Oncology Group; PS, performance status; Squamous, squamous cell carcinoma; Nonsquamous includes adenocarcinoma, carcinoma with neuroendocrine features, NOS NSCLC, sarcomatoid carcinoma, and large cell carcinoma; NA, not available.