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. 2023 Mar 15;615(7953):712–719. doi: 10.1038/s41586-023-05793-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a,b, Co-staining of oil red o and hematoxylin in OXPHOS^HI LUAD and OXPHOS^LO LUSC tumors from xenografts of human cells (a: H1975, RH2) and GEMMs (b: KL). Scale bar = 400 μm. c,d, The expression levels of Plin5 and DGAT1 in LUAD and LUSC tumors from The Cancer Genome Atlas (TCGA) analysis (n = 364 LUAD cells, n = 527 LUSC cells). Unpaired two-tailed t-test. e, Representative confocal Airyscan images stained with MitoTracker DeepRed (MTDR, purple), bodipy (green) and Hoechst (blue) in cultured human LUAD (H1651) and HNSCC (Tu686) cells. Scale bar = 5 μm. f, Quantification of total area of LDs per cell in human LUAD and SCC cells. Data are mean ± s.e.m. (n = 3 biological replicates, n > 300 cells per cell line). Unpaired two-tailed t-test. g, Heat map showing the percentage of mitochondrial population classified by both spatial distribution and cristae types in OXPHOS^HI LUAD cells. Data are mean value from n = 3 biological replicates (n > 1,200 mitochondria). h, Percentage of change in maximal OCR of human LUAD and SCC cells in response to UK-5099, ETO and BPTES. Data are mean ± s.e.m. (n = 3 biological replicates), unpaired two-tailed t-test.

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