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. 2023 Mar 15;615(7953):712–719. doi: 10.1038/s41586-023-05793-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a, Representative transverse images of PET/CT probed with ¹⁸F-BnTP (top) and ¹⁸F-FDG (bottom) in KrasG12D/+; Lkb1^−/− (KL) mice. Uptake of PET probe was measured by the maximum percentage of inject dose per gram (%ID/g). Ratio of %ID/g by tumor to %ID/g by heart is labeled as %ID/g (tumor/heart). H-heart, T-tumor. b, Whole cell lysates of lung tumors T1 and T2 isolated from KrasG12D/+; Lkb1^−/−; p53^−/− (KPL) mouse were immunoblotted with the antibodies of GLUT1 and SP-C. c,d, Immunohistochemical staining of TTF-1 and CK-5 in sections from ¹⁸F-BnTP^HI tumor (mouse 2, left panel) and ¹⁸F-BnTP^LO tumor (T2 in mouse 3, right panel). Scale bar = 500 μm. e,f, Maximal respiration capacity (MRC) of mitochondrial Complex I (CI) and Complex II (CII) isolated from frozen tissues of T1 and T2 in mouse 1 (KPL) (e) and from T in mouse 2 (KL) and T2 in mouse 3 (KL) (f). Data are n = 3 technical replicates, box was interleaved low-high, line at mean. g,h, MRC of Complex I and Complex II in LUAD and LUSC from KPL mice (n = 8 tumors, 3 LUAD tumors and 5 LUSC tumors) (g) and from KL mice (n = 13 tumors, 7 LUAD tumors and 6 LUSC tumors) (h). Data are mean ± s.e.m., unpaired two-tailed t-test.

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