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. 2023 Mar 15;615(7953):712–719. doi: 10.1038/s41586-023-05793-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a,b,c, Transverse view and 3D reconstruction of PET/CT overlayed images probed with ¹⁸F-BnTP (a,c) and ¹⁸F-FDG (b) of ¹⁸F-FDG^HI LUSC tumor in Fig. 2b (a) and ¹⁸F-BnTP^HI LUAD tumor (b,c). d, MicroCT image showed the position of tumor (white outlined) in the lung lobe (orange outlined). Dense tumor region is distinguished from tissue sparse necrotic area (brown outlined) by tissue density. e,h, Hematoxylin and eosin (H&E) staining of sections from OXPHOS^LO LUSC tumor (e) and OXPHOS^HI LUAD tumor (h). Scale bar = 500 μm. (e) Arrows indicated necrotic area and selected region for SBEM imaging in OXPHOS^LO LUSC tumor. (h) Arrow indicated the tumor landmark, box indicated selected region for SBEM imaging in OXPHOS^HI LUAD tumor. f, High-resolution microCT image of selected SBEM region with high ¹⁸F-FDG signal and dense tumor tissue indicated in (e). Scale bar = 200 μm. g,i, Cross-sections of XY, YZ and XZ planes in 3D rendered microCT images on heavy-metal stained OXPHOS^LO LUSC tumor (g) and OXPHOS^HI LUAD tumor (i). Selected regions for SBEM imaging were indicated in the red boxes.