Extended Data Table 1.
Antiviral activity of JNJ-1802 against various RNA and DNA viruses
EC50, 50% effective concentration; CC50, 50% cytotoxic concentration; SI, selectivity index (= CC50/EC50); NC, not calculated; ADV, adenovirus; CHIKV, chikungunya virus; HBV, hepatitis B virus; hCMV, human cytomegalovirus, HCV, hepatitis C virus; HIV-1, human immunodeficiency virus 1; HRV, human rhinovirus; INF-A, influenza A; INF-B, influenza B; JEV, Japanese encephalitis virus; RSV, respiratory syncytial virus; VACV, vaccinia virus; rVSV, recombinant vesicular stomatitis virus; WNV, West Nile virus; ZIKV, Zika virus. Number of experiments to calculate EC50 and CC50 was n = 1 except for the determination of the EC50 for HBV (n = 2), where mean values were shown. aFold change of the EC50 (respective strain)/EC50 (DENV-2/16681). EC50 (DENV-2/16681) = 0.059 nM (see also Table 1). bEC50 was not calculated since antiviral activity was associated with similar level of cytotoxicity. cHuh-7-Luc are HCV-Luc replicon containing cells used to measure the activity of the compound. dHuh-7-CMV-Luc cells were used to measure the toxicity of the compound.