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. 2023 Mar 6;29(3):646–655. doi: 10.1038/s41591-023-02216-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — A. Tumor mutation profiles: Heatmap of somatic driver mutations (including missense, nonsense, and splicing); B. Venn diagrams showing the number of mutations shared between the left (pink) and the right (purple) primary tumors of a same patient; C: Copy number alterations (CNA); D: Mutational signatures profiles as published by Alexandrov²⁵ are calculated using the deconstructSigs package.; E: Fishplots retracing phylogeny between left, right primary tumors. Abbreviations: L, left; R, right; RD, TNBC, triple negative breast cancer.