Table 1.
Characteristics of patients who received and did not receive anticoagulant prescriptions within 30-days of hospital discharge.
| Characteristics | No anticoagulant within 30 days N=3185 | Anticoagulant within 30 days of hospital discharge N= 807 |
|---|---|---|
| N (%) unless otherwise specified | ||
| Pre-sepsis hospitalization | ||
| Age, median [IQR] | 80.0[71.0, 87.0] | 75.0 [67.0, 82.0] |
| Race and Ethnicity | ||
| Asian | 398 (12.5) | 104 (12.9) |
| Black | 203 (6.4) | 52 (6.4) |
| Hispanic | 295 (9.3) | 67 (8.3) |
| Other | 35 (1.1) | 7 (0.9) |
| White | 2254 (70.8) | 577 (71.5) |
| Sex, male | 1741 (54.7) | 469 (58.1) |
| Body mass index, median [IQR] |
26.5 [22.9, 31.2] | 29.2 [25.1, 34.9] |
| Smoking history | 1620 (50.9) | 429 (53.2) |
| Atherosclerotic cardiovascular disease score | 0.239 [0.126, 0.416] | 0.223 [0.115, 0.391] |
| Medications prior to sepsis hospitalization | ||
| Anti-platelet | 183 (5.7) | 26 (3.2) |
| Statin | 1570 (49.3) | 480 (59.5) |
| Anti-hypertensive | 2471 (77.6) | 682 (84.5) |
| Charlson comorbidity Index | 3.0 [2.0, 5.0] | 3.0 [1.0, 5.0] |
| Chronic pulmonary disease | 1212 (38.1) | 327 (40.5) |
| Hemiplegia or paraplegia | 46 (1.4) | 7 (0.9) |
| Acquired Immunodeficiency Syndrome | <5 | <5 |
| Chronic kidney disease | 1417 (44.5) | 362 (44.9) |
| Dementia | 219 (6.9) | 8 (1.0) |
| Diabetes | 1180 (37.0) | 370 (45.8) |
| Diabetes with chronic complications | 909 (28.5) | 287 (35.6) |
| Malignancy, including leukemia and lymphoma | 646 (20.3) | 108 (13.4) |
| Mild liver disease | 87 (2.7) | 13 (1.6) |
| Metastatic solid tumor | 184 (5.8) | 16 (2.0) |
| Peptic ulcer disease | 132 (4.1) | 20 (2.5) |
| Peripheral vascular disorder | 948 (29.8) | 228 (28.3) |
| Renal Disease | 1475 (46.3) | 374 (46.3) |
| Rheumatologic disease | 152 (4.8) | 34 (4.2) |
| Moderate or severe liver disease | 38 (1.2) | 6 (0.7) |
| Myocardial Infarction | 515 (16.2) | 122 (15.1) |
| CHA2DS2-VASc Score for Atrial Fibrillation Stroke Risk | 4.0 [3.0, 4.0] | 3.0 [2.0, 4.0] |
| During sepsis hospitalization | ||
| Percentage of cardiac flowsheet with atrial fibrillation, median [IQR] | 27.3 [8.64, 76.0] | 61.5 [24.6, 96.9] |
| Atrial fibrillation diagnosis code (all patients had atrial fibrillation on cardiac flowsheet) | 1996 (62.7) | 715 (88.6) |
| Atrial fibrillation on cardiac flowsheet on day of discharge | 687 (21.6) | 375 (46.5) |
| Maximum Sequential Organ Failure Assessment score | 4.0 [3.0, 6.0] | 3.000 [2.000, 5.000] |
| Laboratory Acute Physiology Score 2 | 111.0 [86.0, 138.0] | 104.0 [80.0, 128.0] |
| Medications | ||
| Anticoagulants | 448 (14.1) | 634 (78.6) |
| Aspirin | 1869 (58.7) | 556 (68.9) |
| Other Antiplatelet | 252 (7.9) | 55 (6.8) |
| Statin | 1549 (48.6) | 515 (63.8) |
| Inotrope (Dobutamine or Milrinone) | 108 (3.4) | 47 (5.8) |
| Vasopressor | 521 (16.4) | 136 (16.9) |
| Other inpatient procedures | ||
| First ejection fraction measure (%), median [IQR] | 60 [55, 65] | 60 [45, 64] |
| Intensive care unit admission | 1349 (42.4) | 366 (45.4) |
| Days of invasive mechanical ventilation, median [IQR] | 0.0 [0.0, 0.0] | 0.0 [0.0, 0.0] |
| Any invasive mechanical ventilation, N (%) | 397 (12.5) | 120 (14.9) |
| Days of non-invasive mechanical ventilation, median [IQR] | 0.0 [0.0, 0.0] | 0.0 [0.0, 0.0] |
| Any non-Invasive mechanical ventilation, N (%) | 515 (16.2) | 181 (22.4) |
| Hemodialysis | 94 (3.0) | 21 (2.6) |
| Head Computed tomography scan | 351 (11.0) | 57 (7.1) |
| Coronary artery bypass graft procedure | 16 (0.5) | 10 (1.2) |
| Percutaneous intervention procedure | 35 (1.1) | 11 (1.4) |
| Red blood cell transfusion | 445 (14.0) | 51 (6.3) |
| Cryoprecipitate transfusion | 62 (1.9) | 12 (1.5) |
| Platelet transfusion | 78 (2.4) | 9 (1.1) |
| Total blood product volume | 0.0 [0.0, 0.0] | 0.0 [0.0, 0.0] |
| Any blood product, N(%) | 503 (15.8) | 57 (7.1) |
| Other diagnoses during hospitalization | ||
| Peripheral arterial disease | 14 (0.4) | 5 (0.6) |
| Bleeding | 458 (14.4) | 73 (9.0) |
| Fall | 412 (12.9) | 41 (5.1) |
| Malignancy | 343 (10.8) | 36 (4.5) |
| Dementia | 355 (11.1) | 16 (2.0) |
| Heart failure | 1000 (31.4) | 366 (45.4) |
| Myocardial infarction | 237 (7.4) | 74 (9.2) |
| Hospital baseline vital signs and laboratory values (median [IQR]) | ||
| Systolic blood pressure mmHg | 139 [126, 152] | 139 [126, 152] |
| Heart rate, beats per minute | 86 [75, 96] | 89 [77, 100] |
| Hemoglobin | 10.0 [8.6, 11.3] | 10.7 [9.4, 12.0] |
| Hemoglobin A1c % | 6.5 [5.9, 7.9] | 6.5 [6.0, 7.8] |
| Blood urea nitrogen | 21.0 [15.0, 33.0] | 22.0 [16.0, 33.8] |
| Platelets, x 103 | 199 [144, 273] | 208 [158, 281] |
| Creatinine | 0.97 [0.74, 1.35] | 1.01 [0.78, 1.38] |
| Hospital most extreme selected laboratory values (median [IQR]) | ||
| Troponin I | 0.07 [0.03, 0.36] | 0.08 [0.03, 0.36] |
| Brain Natriuretic Peptide | 507 [249, 958] | 539 [299, 942] |
| Creatinine | 1.45 [1.05, 2.22] | 1.44 [1.04, 2.04] |
| Lactic Acid | 2.0 [1.4, 3.3] | 1.9 [1.3, 2.9] |
| Prothrombin time | 15.1 [14.0, 16.5] | 16.3 [14.8, 20.3] |
| Lowest platelet count x 103 | 150 [109, 203] | 151 [115, 203] |
| Hospital length of stay, days | 5.4 [3.7, 8.0] | 5.3 [3.8, 8.0] |