Table 1.
Changes in drinking patterns (Mean (SD)) following acute and chronic CBD administration.
| Outcomes | Baseline (grand mean) | Vehicle (grand mean) | 5 mg/kg CBD | 10 mg/kg CBD | 20 mg/kg CBD | 40 mg/kg CBD | CBD effect: ANOVA F (or Friedman’s test χ2)a | p-value |
|---|---|---|---|---|---|---|---|---|
| Acute (15-min) CBD Pretreatment (N=5) | ||||||||
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| Time to first drink (s) | 4.6 (0.5) | 5.1 (2.0) | 3.8 (0.7) | 4.2 (0.8) | 4.0 (0.9) | 4.4 (0.8) | χ2 = 5.49 | p = 0.60 |
| Total # drinks | 22.9 (4.3) | 25.0 (5.9) | 21.6 (7.6) | 27.4 (8.4) | 24.4 (10.3) | 23.0 (6.9) | F (1,12) = 3.27 | p = 0.72 |
| Total # Bouts | 3.0 (1.8) | 3.0 (1.5) | 2.0 (1.0) | 3.4 (2.1) | 3.6 (2.8) | 3.6 (1.8) | F (1,12) = 0.55 | p = 0.50 |
| Median inter-bout-interval (s) | 1354.0 (677.1) | 1121.0 (406.9) | 1381.0 (336.2) | 1197.0 (187.2) | 953.5 (656.2) | 639.3 (310.2) | F (1,6) = 0.47 | p = 0.57 |
| # drinks in Bout 1 | 14.2 (4.1) | 14.7 (4.8) | 17.0 (8.9) | 17.8 (6.2) | 13.8 (8.4) | 11.6 (3.1) | F (1,12) = 1.47 | p = 0.27 |
| Bout 1 duration | 416.3 (171.4) | 510.7 (370.3) | 428.1 (230.7) | 494.1 (225.1) | 325.9 (316.5) | 455.6 (271.1) | F (1,12) = 0.28 | p = 0.62 |
| Inter-drink-interval in Bout 1 (s) | 10.2 (7.4) | 11.4 (11.2) | 11.1 (12.5) | 5.3 (1.8) | 5.8 (1.5) | 8.1 (5.4) | χ2= 6.78 | p = 0.45 |
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| Acute (90-min) CBD Pretreatment (N=6) | ||||||||
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| Time to first drink (s) | 11.6 (14.7) | 8.5 (8.8) | 4.6 (1.1) | 4.3 (0.4) | 4.7 (0.7) | 5.4 (1.5) | χ2 = 8.40 | p = 0.30 |
| Total # drinks | 22.7 (8.1) | 23.0 (8.6) | 25.3 (13.4) | 25.3 (12.6) | 24.3 (10.9) | 23.3 (11.2) | F (1,12) = 1.31 | p = 0.30 |
| Total # Bouts | 3.2 (1.3) | 2.5 (0.9) | 2.8 (1.6) | 2.5 (1.2) | 3.2 (3.1) | 2.5 (1.6) | F (1,12) = 0.31 | p = 0.60 |
| Median inter-bout-interval (s) | 1135.0 (388.2) | 1116.0 (462.1) | 1297.0 (1394.0) | 1678.0 (1995.0) | 553.9 (356.5) | 719.5 (504.8) | F (1,3) = 28.74 | p = 0.12 |
| # drinks in Bout 1 | 13.0 (4.0) | 15.6 (6.7) | 17.2 (10.9) | 17.0 (14.8) | 14.5 (5.7) | 13.0 (8.3) | F (1,12) = 0.03 | p = 0.88 |
| Bout 1 duration | 566.9 (411.6) | 752.1 (775.4) | 888.2 (953.3) | 935.2 (1464.0) | 595.1 (497.0) | 606.1 (535.3) | F (1,12) = 0.002 | p = 0.97 |
| Inter-drink-interval in Bout 1 (s) | 18.3 (13.3) | 20.7 (18.8) | 19.2 (16.5) | 44.3 (53.6) | 13.4 (9.1) | 18.4 (13.7) | χ2= 0.84 | p = 0.99 |
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| 5-Day Chronic (15-min) CBD Pretreatment (N=7) | ||||||||
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| Time to first drink (s) | 35.9 (72.6) | 75.4 (167.9) | -- | 39.1 (87.2) | 18.6 (34.3) | 148.1 (339.7) | χ2 = 3.86 | p = 0.28 |
| Total # drinks | 21.8 (6.1) | 22.7 (8.7) | -- | 22.5 (5.6) | 23.4 (7.0) | 21.7 (8.6) | F (1.98, 11.88) = 0.39 | p = 0.69 |
| Total # Bouts | 3.4 (1.2) | 3.6 (1.3) | -- | 3.9 (1.2) | 3.9 (1.2) | 3.8 (1.8) | F (2.27, 13.61) = 0.27 | p = 0.80 |
| Median inter-bout-interval (s) | 1556.0 (1044.0) | 1219.0 (846.5) | -- | 1286.0 (797.7) | 1224.0 (658.7) | 1254.0 (627.8) | F (1.27, 7.64) = 0.06 | p = 0.87 |
| # drinks in Bout 1 | 10.4 (5.1) | 10.7 (9.2) | -- | 9.8 (7.0) | 10.9 (8.1) | 8.9 (6.0) | F (1.33, 7.97) = 0.52 | p = 0.54 |
| Bout 1 duration | 444.8 (438.6) | 516.1 (783.5) | -- | 365.4 (462.7) | 495.9 (724.9) | 408.2 (595.9) | F (1.21, 7.28) = 1.32 | p = 0.30 |
| Inter-drink-interval in Bout 1 (s) | 21.7 (20.4) | 42.7 (70.0) | -- | 14.3 (13.8) | 21.3 (24.0) | 24.3 (32.2) | χ2= 3.00 | p = 0.39 |
Notes: SD = standard deviation, s = seconds, CBD = Cannabidiol, # = number.
a
Friedman’s test was used in data that were largely non-normal.