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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Drug Alcohol Depend. 2023 Mar 1;245:109829. doi: 10.1016/j.drugalcdep.2023.109829

Table 2.

Performance on the fine motor task (M&Ms retrieved, dropped, and time to complete task; Mean (SD)) and observations of adverse behavioral effects during chronic CBD treatment following alcohol self-administration session completion (Post-Session) and 24 hours after CBD administration. Data are number of baboons (n=7) with symptoms present on any of the five days.

Characteristics Vehicle 10 mg/kg CBD 20 mg/kg CBD 40 mg/kg CBD
Fine Motor Task Post-Session
M&Ms Taken (%) 100 100 100 100
M&Ms Dropped (%) 4.3 2.9 1.4 3.3
Time (sec) to complete task (SD) 7.4 (2.6) 7.4 (2.4) 7.0 (1.3) 7.8 (2.5)
Behavioral Observations Post-Session
Ataxia 0/7 0/7 0/7 0/7
Slow in Moving 5/7 3/7 3/7 3/7
Lip Droop 0/7 0/7 0/7 0/7
Limb Tremor 0/7 0/7 0/7 0/7
Body Tremor 0/7 0/7 0/7 0/7
Fine Motor Task 24-hours After CBD Administration (Pre-Session)
M&Ms Taken (%) 100 100 100 100
M&Ms Dropped (%) 1.4 2.4 1.4 1.0
Time (sec) to complete task (SD) 7.6 (2.7) 7.8 (2.1) 8.8 (8.4) 7.6 (1.7)
Behavioral Observations 24-hours After CBD Administration (Pre-Session)
Ataxia 0/7 0/7 0/7 0/7
Slow in Moving 1/7 2/7 1/7 2/7
Lip Droop 0/7 0/7 0/7 0/7
Limb Tremor 1/7 3/7 1/7 0/7
Body Tremor 0/7 0/7 0/7 0/7

Notes: SD = standard deviation, % = percent of total trials, CBD = Cannabidiol