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. 2023 Mar 16;29(3):632–645. doi: 10.1038/s41591-022-02178-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — Bio-informatic deconvolution of RNA-seq data was applied to a previously reported clinical series of 72 newly diagnosed MM patients (GSE104171), which allowed the definition of the cellular composition of the BM microenvironment^34,35. a) These studies confirmed the presence of the MM immunological subgroups, which divided the patients into two immune categories according to the abundance of immune cells in the BM. b) In this clinical series, patients with abundant immune cells MM (28 cases, 39%) presented higher number of PD-1⁺CD8⁺ T cells and T_reg cells with respect to those patients with low-infiltrating MM cases (44 cases, 61%). c) In addition, the transcriptomic signatures corresponding to CD8⁺ T cells, T_reg cells, NK cells and T_helper type 1 and type 2 cells were increased in the cases with higher number of immune cells with respect to those with less abundant T and NK cells.