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. 2023 Mar 8;615(7953):660–667. doi: 10.1038/s41586-023-05796-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a,b, Nestin-cre; Ptger3^flox (a), Advillin-cre^ER; Ptger3^flox mice (b) or Ptger3^flox (a,b) mice were infected with influenza A virus and monitored as indicated. Data are mean ± s.e.m.; n = 8 mice (Ptger3^flox), n = 6 mice (Nestin-cre and Advillin-cre^ER). Two-tailed unpaired t-test as detailed in Fig. 1 for behaviour or physiology analyses; log-rank (Mantel–Cox) test for survival analysis. a, Food intake: P = 0.0126; water intake: P = 0.1006; motility: P = 0.0701; body weight: P = 0.9361; survival: P = 0.7735. b, Food intake: P = 0.0004; water intake: P = 0.0004; motility: P < 0.0001; body weight: P = 0.0004; survival: P = 0.0216. c, The NJP ganglia of Ptger3^flox mice were injected bilaterally with AAV-cre, exposed to influenza A virus or saline and monitored as indicated. Data are mean ± s.e.m.; n = 8 mice per group. Ptger3^flox, virus—food intake: P < 0.0001; water intake: P < 0.0001; motility: P < 0.0001; body weight: P < 0.0001; survival: P < 0.0001. Ptger3^flox; AAV-cre, virus—Food intake: P < 0.0001; water intake: P < 0.0001; motility: P < 0.0001; body weight: P < 0.0001; survival: P = 0.0376. One-way ANOVA with Dunnett’s multiple comparison test as detailed in Fig. 1 for behaviour or physiology analyses; log-rank (Mantel–Cox) test for survival analysis, with comparisons made between Ptger3^flox, virus and Ptger3^flox; AAV-cre, vehicle (red stars) or between Ptger3^flox, virus and Ptger3^flox; AAV-cre, virus (blue stars).

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