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. 2023 Mar 8;615(7953):660–667. doi: 10.1038/s41586-023-05796-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, A uniform manifold approximation and projection (UMAP) plot derived from published single-cell transcriptome data of vagal and glossopharyngeal sensory ganglia²² showing expression of indicated genes (colour shows relative expression on a natural log scale). b, Cell types, as highlighted in a, express the indicated gene as well as Ptger3. Mice were infected with influenza A virus and monitored as indicated. Data are mean ± s.e.m.; n = 8 (Piezo2-IRES-cre), n = 6–8 (Phox2b-cre; 8 control and 6 Phox2b-cre), n = 6 (Pdyn-IRES-cre), n = 6 (Oxtr-IRES-cre) and n = 10 (Gabra1-IRES-cre) mice per group. Two-tailed unpaired t-test as detailed in Fig. 1 for behaviour or physiology analyses; log-rank (Mantel–Cox) test for survival analysis. Piezo2-IRES-cre—food intake: P = 0.2631; motility: P = 0.2680; body weight: P = 0.7925; survival: P = 0.4736. Phox2b-cre—food intake: P < 0.0001; motility: P < 0.0001; body weight: P = 0.0002; survival: P = 0.0181. Pdyn-IRES-cre—food intake: P = 0.4539; motility: P = 0.4946; body weight: P = 0.2675; survival: P = 0.7937; Oxtr-IRES-cre—food intake: P = 0.4786; motility: P = 0.6333; body weight: P = 0.3297; survival: P = 0.7121; Gabra1-IRES-cre—food intake: P = 0.0001; motility: P < 0.0001; body weight: P = 0.0004; survival: P = 0.0263.

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