Table 4.

Association^* of Liver Fibrosis with Standardized Cognitive Test Performance and Brain MRI Parameters in the UK Biobank

Outcome Measure	Primary Approach: Liver Fibrosis versus no Liver Fibrosis	Secondary Approach: For each 1.0 unit increase in FIB-4
Digit Symbol Substitution Test	−0.06 (P<0.001)	−0.02 (P<0.001)
Trail Making Test A	0.07 (P=0.002)	0.05 (P<0.001)
Trail Making Test B	0.09 (P<0.001)	0.03 (P=0.008)
Reaction Time Test	0.04 (P<0.001)	0.03 (P<0.001)
Numeric Memory Test	−0.01 (P=0.602)	−0.00 (P=0.845)
Pair Matching Test	0.02 (P=0.358)	0.00 (P=0.896)
White matter hyperintensity volume	0.05 (P=0.196)	0.05 (P=0.019)
Hippocampal volume	−0.17 (P<0.001)	−0.09 (P<0.001)
Total brain volume	−0.07 (P=0.061)	−0.10 (P<0.001)

Abbreviations: No., number; FIB-4, Fibrosis-4 score.

^*Results of multivariable linear regression reported as beta (P value). The outcome measures were natural log transformed and then standardized (mean=0, standard deviation=1) to permit comparison of effect size across outcomes. Models were adjusted for age at time of test/imaging, time from baseline to test/imaging, sex, race/ethnicity, educational attainment, socioeconomic deprivation, hypertension, diabetes, dyslipidemia, body mass index, metabolic syndrome, smoking, and alcohol intake frequency. MRI-derived measures were adjusted for total intracranial volume, and models for these measures were additionally adjusted for acquisition site.