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. 2023 Feb 22;482(3):551–560. doi: 10.1007/s00428-023-03516-7

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Morphological, immunohistochemical, and genetic features of LBCL-IRF4 (case no. 35). a Large B-cell lymphoma with blastoid morphology with medium-sized cells, inconspicuous nucleoli, and scant cytoplasm (original magnification × 200; hematoxylin and eosin stain); b with original magnification × 400: hematoxylin and eosin stain; c original magnification × 400: Giemsa stain. d MUM1. e CD10. f Fluorescence in situ hybridization (FISH) analysis using a break apart probe (BAP) demonstrates an IRF4 break with 1 colocalized signal (yellow arrow) and 1 split signal (green and red arrows) consistent with gene rearrangement. g FISH analysis with a BAP demonstrates an IGH break with 1 colocalized signal (yellow arrow) and 1 split signal (green and red arrows) consistent with gene rearrangement (Fig. 1 was created using Adobe Photoshop Version CS6)