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. 2023 Mar 9;14:1135815. doi: 10.3389/fimmu.2023.1135815

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Copyright © 2023 Carter, Huang, Liu, Liang, Lin, Peng, McKay, Dimitrakakis, Hsu, Tat, Saenkham-Huntsinger, Chen, Kaseke, Gaiha, Xu, Griffiths, Tam, Tseng and Gifford

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study phenotypic data, lung viral titer, and vaccine antibody responses. (A) Weights vs. days post infection, (B) clinical scores vs. days post infection, (C) Kaplan-Meier mortality curve (mortality at 80% weight loss), (D) lung viral titer, (E) maximum serum dilution that provided 100% neutralization of viral infection in vitro, (F) IgG/IgM titer measured by ELISA against cell lysate infected with WA-1 SARS-CoV-2. Dotted lines in (D–F) indicate assay limits of detection. Error bars indicate the standard deviation around each mean. P values were computed by one-way ANOVA with Tukey’s test except (C) P values were computed using the logrank test. *P < 0.05 and **P < 0.01.