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. 2023 Mar 9;17:1061485. doi: 10.3389/fnins.2023.1061485

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Copyright © 2023 Venkat, Gao, Findeis, Chen, Zacharek, Landschoot-Ward, Powell, Lu, Liu, Zhang and Chopp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD133 + Exo treatment of T2DM stroke significantly increases vascular and white matter/axon remodeling. (A,B) CD133 + Exo treatment of T2DM-stroke significantly increases arterial blood vessel density (αSMA) and vessel density (vWF) in the ischemic brain compared to T2DM-stroke mice. (C,D) CD133 + Exo treatment of T2DM-stroke significantly increases axon density (Bielschowsky silver, BS) and myelin density (Luxol fast blue, LFB) in the ischemic brain compared to T2DM-stroke mice at 28 days after stroke. T2DM (n = 8), T2DM-stroke (n = 12), and T2DM-stroke + Exo (n = 13).