Figure 1.

Multimodal retinal imaging of both eyes, 11 months before death. Fluorescein angiography (FA) in the venous (A) and recirculation phases (D) showed multiple instances of hyperfluorescence. Vessels were found by histology at the green, yellow, and fuchsia arrowheads in the right eye (A) and left eye (D). At the white arrowhead in the left eye, no vessel could be found in histology. B, E, Near-infrared reflectance imaging (NIR) shows reduced reflectance in areas of angiographic leakage (arrowheads), possibly because of retinal edema. Soft drusen exhibit hypo- and hyperreflective mottling. Scale bar = 200 μm. C, F, Fundus autofluorescence (FAF) (λ_ex= 488 nm) highlights subretinal drusenoid deposits, especially superior to the fovea. Lesion number, type, and spatial distribution are listed in Table 2. OD = right eye; OS = left eye.