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. 2023 Feb 10;3(3):100280. doi: 10.1016/j.xops.2023.100280

Figure 5.

Figure 5

Multimodal imaging, clinical course, and histology of pyramidal type 3 macular neovascularization (MNV), left eye (OS) 4. A, Venous phase fluorescein angiography (FA) (A1) shows mild leakage at the site of type 3 MNV 11 months before death. Green lines on FA represent OCT B-scans. A horizontal OCT B-scan (A2) displays a hyperreflective lesion, hyperreflective foci (HRF), and small intraretinal cysts. B, Blue lines on near-infrared reflectance imaging (NIR) (B1) represent histology section in (D). Radial OCT B-scan (B2) displays enlarged intraretinal cysts after 5 total injections and 8 weeks after the prior injection. There is also a subsidence of the outer plexiform layer (OPL) and external limiting membrane (ELM). C, On radial OCT B-scan (C2), intraretinal fluid is reduced after 6 injections and 6 weeks after the prior injection. Numerous HRF are present in the inner nuclear layer (INL) (C2); scale bar = 200 μm. D, On histology, type 3 MNV is a pyramidal complex bounded by retinal pigment epithelium (RPE) cells. It extends from the INL/OPL border to the basal laminar deposit (BLamD) draping a calcified druse. Structural damage to the Henle fiber layer at the right of the panel (green asterisk) may indicate an area of prior intraretinal fluid. Magnified histology is shown in Figure 6. Scale bar = 100 μm. Blue line, histology section. Time in months and time before death.