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. 2023 Feb 24;14(12):3215–3228. doi: 10.1039/d3sc00411b

Summary of factors that alter CORM-A1 CO production.

Aspect probed Reagents used Effect on CO production
Buffer/phosphate anions Phosphate buffered saline, lithium phosphate buffer Concentration-dependent acceleration
CO-independent redox activity NAD+, NADP+, NADH, 1-methylnicotinamide Acceleration
Oxidants H2O2, DMSO Inhibition
Oxidants in DMSO DDQ, ODQ Reversal of inhibition; indicating chemical reactivity
Cations (organic and inorganic) N-Methyl pyridine, N-methyl DABCO, Na+ (in PBS and NaCl) and Li+ (in lithium phosphate buffer) No effect
Biological media DMEM (10% FBS) Acceleration (when compared to PBS)
Biological Media RMPI (starved) Decrease of initial CO production