Figure 6.

NTSR1 protein biology’s graphical summary. Illustration of NTSR1 biology: 1-NTSR1 is expressed as the NTSR1-LP and co-translationally glycosylated in the ER (Fig. 3); 2-NTSR1 is transported and processed in the Golgi to form the NTSR1-high form Fig. 3; 3-NTSR1 is delivered to the plasma membrane (Figs. 3,5); 4-NTSR-high is cleaved by MMP to form the NTSR1-low protein form (Fig. 4); 5-NTS promotes NTSR1 internalization (Fig. 5); 6-NTSR-low form is degraded by the proteasome (Fig. 5)