Fig. 2.

Mean unbound CIP concentrations normalized by the CIP dose measured in ELF (black circle) and in plasma (open square) versus time after IV administration of a CIP solution (A), and after IT administration of CIP-Cu-loaded particles (B). The CIP dose was 2.5 mg/kg for all animals. The unbound plasma fraction was fixed at 59% of the total CIP concentration according to Roosendaal et al. (Roosendaal et al., 1987). Data points represent averaged values ± standard deviation (SD) of 3–7 individual measurements.