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. 2023 Jan 25;14(3):507–519. doi: 10.1039/d2md00149g

Effect of 3b and 9e on the methyltransferase activities of the nsp10–nsp16 complex and nsp14. S-Adenosyl-l-homocysteine (SAH) was used as control.

Compound name IC50nsp10–nsp16 (μM) Hill slope IC50nsp14 (μM) Hill slope
SAH 3.9 1.1 0.22 0.8
3b NI NA NI NA
9e NI NA >100 NA