Effect of 3b and 9e on the methyltransferase activities of the nsp10–nsp16 complex and nsp14. S-Adenosyl-l-homocysteine (SAH) was used as control.
Compound name | IC50nsp10–nsp16 (μM) | Hill slope | IC50nsp14 (μM) | Hill slope |
---|---|---|---|---|
SAH | 3.9 | 1.1 | 0.22 | 0.8 |
3b | NI | NA | NI | NA |
9e | NI | NA | >100 | NA |