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. 2023 Mar 9;13:1122508. doi: 10.3389/fonc.2023.1122508

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Copyright © 2023 Fuchs, Schulte, Fuchs and Agulnik

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simplified mechanisms of action of targeted therapies for treatment of soft tissue sarcoma. *Indicates that medication is FDA approved for treatment of certain soft tissue sarcoma subtypes. Key: Platelet derived growth factor receptor (PDGFR); vascular endothelial growth factor receptor (VEGFR); stem cell growth factor receptor (c-kit); Hepatocyte Growth Factor Receptor (c-Met); Anaplastic Lymphoma Kinase (ALK); cyclin dependent kinase (CDK); colony stimulating factor 1 (CSF1); enhancer of zeste homolog 2 (EZH2); retinoblastoma (RB).