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. 2023 Mar 9;14:1087654. doi: 10.3389/fphar.2023.1087654

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Copyright © 2023 Qin, Zhang, Bian, Fei, Su, Xue, Zhang, Li, Chen, Shi, Li, Mao, Zhao, Ji and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RT-qPCR, WB, and FA metabolomics results of CW against PD. (A) Gene expression levels of 5-HTR2A, IP3R, PKC, cALM, and ERK in the uterine tissues of rats in each group (x‾ ± s, n = 3). (B) Protein expression levels of p-ERK and ERK in the uterine tissues of rats in each group (x‾ ± s, n = 3). (C) The proportion of SFA, MUFA, and PUFA in liver tissues (x‾ ± s, n = 6). (D) n6 PUFAs (x‾ ± s, n = 6). (E) n3 PUFAs (x‾ ± s, n = 6). (F) n6/n3 ratio (x‾ ± s, n = 6). Compared with the NC group, *p < 0.05, **p < 0.01, ***p < 0.001; compared with the M group, ^# p < 0.05, ^## p < 0.01, ^### p < 0.001. NC, Normal control group; M, Model group, CW-H, CW high-dose group; IBP, Ibuprofen positive control group.