TABLE 5.

Meta-regression analysis of potential sources of animal studies heterogeneity.

Heterogeneity factor	Coefficient	SE	t	p-value	95% CI (lower limit, upper limit)
region	4.255238	2.975009	1.43	0.196	−2.77954, 11.29002
year of publication	3.702559	4.491461	0.82	0.437	−6.91806, 14.32318
whether thestudy set the dose subgroup	4.001104	5.08711	0.79	0.457	−8.027999, 16.03021
in vivo or in vitro experiments	−0.779716	5.795373	−0.13	0.897	−14.4836, 12.92416
myocardial ischemia duration	1.391345	2.765627	0.50	0.630	−5.148324, 7.931014
times of administration	0.21975	5.388646	0.04	0.969	−12.52237, 12.961873
animal sample size	2.58827	5.942484	0.44	0.676	−11.46347, 16.64001
publication language	3.311636	7.378133	0.45	0.667	−14.13488, 20.75815
Cutoff value	−35.80981	21.23304	−1.69	0.136	−86.01798, 14.39835

SE, standard error; CI, confidence interval.