Table 3.
Subgroup analysis of the association between Ln HOMA-IR and Ln OSI.
| Subgroups | Subjects n (%) | β (95%CI) | P value | P for interaction |
|---|---|---|---|---|
| Age tertile (y): | 0.5570 | |||
| < 35 | 1415 (93.83%) | -0.18 (-0.26, -0.11) | <0.0001 | |
| ≥ 35 | 93 (6.17%) | -0.11 (-0.45, 0.23) | 0.5300 | |
| BMI categories: | 0.3930 | |||
| Normal weight | 628 (41.64%) | -0.19 (-0.29, -0.09) | 0.0002 | |
| Overweight/obese | 880 (58.36%) | -0.25 (-0.35, -0.16) | <0.0001 | |
| AMH (ng/ml): | 0.2802 | |||
| ≤ 5 | 382 (26.45%) | -0.14 (-0.27, -0.01) | 0.0378 | |
| > 5 | 1062 (73.55%) | -0.21 (-0.30, -0.12) | <0.0001 | |
| Initial Gn dose (IU): | 0.9251 | |||
| < 150 | 891 (59.08%) | -0.18 (-0.27, -0.08) | 0.0002 | |
| ≥ 150 | 617 (40.92%) | -0.16 (-0.28, -0.04) | 0.0089 | |
| COS procotol | 0.9834 | |||
| GnRH agonist | 1268 (84.08%) | -0.18 (-0.26, -0.10) | <0.0001 | |
| GnRH antagonist | 240 (15.92%) | -0.16 (-0.35, 0.03) | 0.1031 |
HOMA-IR, homeostatic model assessment of insulin resistance; BMI, Body Mass Index; AMH, anti-mullerian hormone; COS, controlled ovarian stimulation; Gn, gonadotropin; GnRH, gonadotropin releasing hormone. Adjusted, if not stratified, for age, BMI, AMH, basal FSH, initial Gn dose, AFC, and COS protocol.