. 2023 Mar 9;14:1118788. doi: 10.3389/fphar.2023.1118788

TABLE 2.

Peak concentration of tigecycline in septic shock patients.

Variable	Patient	Non-CRRT (n = 11)	CRRT (n = 6)	p	^a Adjusted p-value
Cmax (ng/mL)	Patient 1	434.71	411.17	0.129	^b –
	Patient 2	228.83	713.65
	Patient 3	269.97	330.52
	Patient 4	271.46	573.16
	Patient 5	366.97	411.65
	Patient 6	400.47	590.55
	Patient 7	477.28	–
	Patient 8	481.50	–
	Patient 9	492.05	–
	Patient 10	504.08	–
	Patient 11	541.91	–
	Mean ± SD	406.29 ± 108.00	505.11 ± 143.84

C_max, Peak concentration; CRRT, continuous renal replacement therapy.

p: Tigecycline concentration was compared between the two groups of patients using unpaired t-test.

^{^a}

Adjusted p-value: Tigecycline concentration was compared between the two groups of patients using multivariate linear regression analysis model, adjusted for variables retained after bootstrap selection.

^{^b}

Multivariate linear regression was not performed for C_max because there is no variable retained after bootstrap selection.