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. 2023 Mar 23;24:219. doi: 10.1186/s13063-023-07252-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Flowchart of “L-PRF in cranial surgery, a prospective randomized controlled trial.” After obtaining informed consent, patients are screened and asked to complete quality of life (QoL) questionnaires (EQ-5D and RAND SF-36). During surgery (i.e., before dural closure), study subjects are randomized into the experimental arm (L-PRF) and the control arm (commercially available fibrin sealants). During hospitalization, patients are followed up with clinical controls after 2 days (FU1) and on the day of discharge (FU2). One outpatient follow-up is done between 6 and 12 weeks postop (FU3), with MRI imaging and completion of the QoL questionnaires