Table 1.
Selected pharmaceutical interventions currently listed in ClinicalTrials.gov * .
| Drug | Drug Class | Proposed Mechanism for PASC | NCT Number |
|---|---|---|---|
| Antiviral | |||
| Favipiravir | SARS-CoV-2 RNA-dependent RNA polymerase inhibitor | Viral clearance or reduction in inflammation | NCT04448119 |
| Nirmatrelvir/ritonavir (Paxlovid) | Protease inhibitor | Viral clearance or reduction in inflammation |
NCT05595369 NCT05576662 |
| Remdesivir | SARS-CoV-2 RNA-dependent RNA polymerase inhibitor | Viral clearance | NCT04978259 |
| Cardiac Agents | |||
| Ivabradine | hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker | Treat postural orthostatic tachycardia syndrome | NCT05481177 |
| Metoprolol succinate | Beta-1 antagonist | Improve cardiac function | NCT05096884 |
| Antiinflammatory agents | |||
| Cannabinoid containing formulations | Cannabinoids | Antiinflammatory |
NCT04997395 NCT05467904 |
| Fluvoxamine | selective serotonin reuptake inhibitor (SSRI) | Improve parosmia | NCT05216614 |
| Ibudilast | Phosphodiesterase Inhibitor | Block Inflammatory pathways | NCT05513560 |
| Imatinib | Kinase inhibitor | Antiinflammatory | NCT05220280 |
| Infliximab | TNF-alpha inhibitor | Antiinflammatory | NCT05220280 |
| Low Dose Naltrexone | Opioid antagonist | Antiinflammatory |
NCT04604704 NCT05430152 |
| Pentoxifylline | Xanthine derivative Hemorrheologic Agent |
Antiinflammatory/immunomodulator Vasodilator |
NCT05513560 |
| Vitamin D | Dietary Supplement | Treat post-COVID Vitamin D deficiency | NCT05633472 |
| Respiratory Agents | |||
| LYT-100 (deupirfenidone) | Antifibrotic | Antifibrotic/antiinflammatory | NCT04652518 |
| Montelukast | leukotriene receptor antagonists | Improve respiratory PASC symptoms | NCT04695704 |
| S-1226 | bronchodilator | Improve respiratory PASC symptoms | NCT04949386 |
| Other | |||
| AXA1125 | Endogenous metabolic modulator | Improve muscle function | NCT05152849 |
| Lithium | Antimanic agent | Improve fatigue and brain fog | NCT05618587 |
| Pimozide | Dopamine receptor antagonist | Treat tinnitus | NCT05507372 |
| RSLV-132 | RNase-Fc fusion protein | Lessen fatigue | NCT04944121 |
| Somatropin | Growth hormone | Resolve associated hormone secretion disorder | NCT03554265 |
| Temelimab | Monoclonal Antibody | Improve cognitive functioning | NCT05497089 |
| TNX-102 (cyclobenzaprine) | Muscle relaxant | Pain | NCT05472090 |
| Vortioxetine | selective serotonin reuptake inhibitor (SSRI) | Improve cognitive functioning | NCT05047952 |
* Search done on 12/02/2022. This list is not all inclusive and excludes non pharmacological interventions (e.g., physical or cognitive therapy, supplements).