. 2023 Mar 9;13:1054072. doi: 10.3389/fonc.2023.1054072

Table 6.

Meta-analysis results of Laboratory-related AEs - Subgroup analysis.

Outcomes	Interventions in the control group	Studies	Participants	Heterogeneity test results		Effect model	Meta-analysis results
Outcomes	Interventions in the control group	Studies	Participants	P	I²	Effect model	95%CI	P
Alanine aminotransferase increased	LEN+PD-1	2	240	0.02	81%	Random	1.47 [0.48, 4.51]	0.50
Alanine aminotransferase increased	LEN+TACE	2	223	0.41	0%	1.15 [0.68, 1.94]	0.61
Aspertate aminotransferase increased	LEN+PD-1	2	240	0.05	74%	Fixed	1.12 [0.65, 1.92]	0.68
Aspertate aminotransferase increased	LEN+TACE	2	223	0.78	0%	1.65 [0.86, 3.17]	0.13
Albumin decreased	LEN+PD-1	2	240	0.39	0%	Fixed	0.94 [0.47,1.88]	0.86
Albumin decreased	LEN	2	157	—	—	—	—

TACE, transcatheter arterial chemoembolization; PD-1, programmeddeath-1; LEN, Lenvatinib. -, not available.