. 2023 Mar 22;6(3):e234198. doi: 10.1001/jamanetworkopen.2023.4198

Table 3. Associations of Symptom Severity Clusters With Longitudinal Adverse Outcomes.

Variable	Hospitalization over 3 mo, RR (95% CI)		Overall survival over 1 y, HR (95% CI)		Any grade 3-5 toxic effect, RR (95% CI)
Variable	Unadjusted model^a	Adjusted model^a^,b	Unadjusted model^a	Adjusted model^a^,^b	Unadjusted model^a	Adjusted model^b^,^c
Symptom cluster, severity
Low	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]	1 [Reference]
Moderate	1.61 (1.20-2.17)	1.36 (1.01-1.84)	1.59 (1.25-22.03)	1.31 (1.01-1.69)	1.05 (0.92-1.19)	1.04 (0.92-1.18)
P value	.02	.046	<.001	.04	.50	.49
High	1.88 (1.32-2.69)	1.44 (0.99-2.10)	2.62 (1.93-3.53)	2.00 (1.43-2.78)	1.11 (0.94-1.31)	1.17 (0.97-1.39)
P value	<.001	.05	<.001	<.001	.21	.10
Patients, No.	706	706	706	706	706	706
Sites, No.	39	39	39	39	39	NA

Abbreviations: HR, hazard ratio; NA, not applicable; RR, risk ratio.

^{^a}

Models included practice site as random effect.

^{^b}

Multivariable models adjusted for age, sex, cancer type, cancer treatment, number of Geriatric Assessment domain impairments, study group, Karnofsky performance status.

^{^c}

Practice site random effect was excluded because the model did not converge.