Figure 4. Change in Normalized Generalized Equivalent Uniform Dose (gEUD) for Clinical Target Volume (CTV) Values Comparing the Adaptive Plans With the Scheduled Plan Accumulated Over All Fractions per Series.

The change in gEUD for CTV values were obtained from the accumulated dose distributions for the adapted and scheduled plans for each of the 10 delivered treatment series and planning target volume (PTV) margins of 5 mm and 0 mm, respectively. The gain by adaption is larger for a PTV margin of 0 mm compared with 5 mm (P = .004; signed rank test for intraseries comparisons). ART indicates adaptive radiotherapy; IGRT, image-guided radiotherapy.