Figure 8.

Structural similarities between T4 Pnk and Adk. The amino acid sequences of B.stearothermophilus (PDB 1ZIN), E.coli (1AKE), Saccharomyces cerevisiae (1AKY) and porcine (3ADK) Adk are aligned with each other and with the N-terminal kinase domain of T4 Pnk. The amino acids of Pnk that are essential for 5′-kinase activity and conserved in Adk are denoted by •. The secondary structure elements of Adk are shown above the aligned sequences. Positions of identity/similarity in all five of the proteins are highlighted in shaded boxes.