FIGURE 1.

Characterization of the pyomelanin‐producing P. aeruginosa strain and the timeline of the dsRNA phage therapy. (A) The P. aeruginosa strain PA‐LX01 from the patient produces the brown pyomelanin, and phiYY lyses this strain efficiently. (B) The results of the antibiotic susceptibility testing for P. aeruginosa strains isolated before and after phage therapy. (C) Growth curve of PA‐LX01 strain in the presence or absence of phiYY. Each assay was repeated three times. (D) The timeline for the three courses of dsRNA phage therapy, which indicated the application of phage and antibiotics. (E) The titre of phage phiYY in the sputum before and after phage therapy.[Correction added on 17 January 2023, after first online publication: the labelling in figure 1C has been updated in this version.]