Fig. 1.

Multimodal imaging of neurovascular coupling for monitoring longitudinal stroke recovery. (a) Simplified imaging schematic and experimental timeline. Note: Imaging schematic only shows green light reflected for convenience, however, all reflected light between 500mn and 640 nm is captured by the camera. (b) SFDI. Top: Tissue scattering coefficients at each time point. Bottom: Stroke core and peri-infarct regions for the above images. (c) Sensory stimulation with IOSI. Top: Block design of each trial in a stimulation session, middle: trial averaged spatial maps of HbO, HbR, HbT, and corrected GCaMP, during 5 sec of air-puff stimulation to the left forelimb, bottom: trial averaged time course of each measurement, note that raw uncorrected GCaMP drops immediately following the rise of the hemodynamic response and corrected GCaMP shows elevated responses through the full stimulation period. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)