Fig. 5.

Global brain oscillations following stroke. (a) Raw time traces of filtered (0.009–0.4 Hz) calcium and hemodynamic signals before and 2 days after stroke within the ipsilesional (top) and contralesional (bottom) hemispheres in ROI marked with pink box. Note the increase in amplitude of HbO in both hemispheres at day 2 and increase in GCaMP amplitude only in the contralesional hemisphere. (b) Histogram of variance in the mean signal, after global signal regression, for GCaMP (left) and HbO (right) at pre-stroke, day 2, and week 4. (c) Frequency spectrum of the power of the GCaMP (left) and HbO (right) signal in the ipsilesional (top) and contralesional (bottom) hemispheres. (d) Area under the curve within 0.1–0.3 Hz frequency band. Thick bars: p < 0.01, thin bars: p < 0.05. (e) Spatial maps of average power across 0.009–0.4 Hz frequency band for GCaMP (top) and HbO (bottom) at each time point. Yellow asterisk indicates the stroke hemisphere. (f) Mean power assessed in each hemisphere within the forelimb and non-forelimb areas. A two-sample t-test was run for all statistical tests. Thick bars: p < 0.01, thin bars: p < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)