The personality profile of bipolar disorder. (a) Systematic Treatment Enhancement Program genetic repository (STEP-GRP) participants (total n=982); (b) STEP standard care pathway (STEP-SCP) participants (total n=1267). Data are NEO Five-Factor Inventory (NEO-FFI) t scores where available from study entry (–■–, n=882 and n = 1216), assessment during euthymic state (--◆--, n=525 and n=651), and symptom-adjusted scores (⋯▲⋯ n=982 and n=1267) from structural equation models. Values are means, with standard errors represented by vertical bars. —, Population mean=50 (s.d.=10) (Costa & McCrae, 1992). N, Neuroticism; E, extraversion; O, openness to experience; A, agreeableness; C, conscientiousness.