Table 1.
STEP-GRP |
STEP-SCP |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline |
12 Months |
24 Months |
Baseline |
12 Months |
24 Month |
|||||||
β | p | β | p | β | p | β | p | β | p | β | p | |
Depression | ||||||||||||
Neuroticism | 0.16 | <0.001 | 0.27 | <0.001 | 0.38 | <0.001 | 0.20 | <0.001 | 0.25 | <0.001 | 0.37 | <0.001 |
Extraversion | −0.23 | <0.001 | −0.25 | <0.001 | −0.20 | 0.002 | −0.22 | <0.001 | −0.27 | <0.001 | −0.28 | <0.001 |
Openness | −0.09 | 0.02 | −0.02 | n.s | −0.11 | 0.04 | −0.10 | 0.007 | −0.09 | n.s | −0.04 | n.s |
Agreeableness | −0.11 | 0.02 | −0.07 | n.s | −0.09 | n.s | −0.09 | 0.03 | −0.07 | n.s | −0.24 | <0.001 |
Conscientiousness | −0.15 | 0.004 | −0.19 | <0.001 | −0.26 | <0.001 | −0.19 | <0.001 | −0.27 | <0.001 | −0.21 | 0.02 |
Mania | ||||||||||||
Neuroticism | 0.14 | n.s | −0.06 | n.s | 0.01 | n.s | 0.00 | n.s | −0.06 | n.s | −0.03 | n.s |
Extraversion | 0.18 | 0.03 | 0.26 | 0.006 | 0.28 | 0.02 | 0.05 | n.s | 0.10 | 0.04 | 0.17 | 0.02 |
Openness | 0.06 | n.s | −0.05 | n.s | 0.10 | n.s | 0.05 | n.s | 0.07 | n.s | 0.17 | 0.01 |
Agreeableness | −0.19 | 0.02 | −0.08 | n.s | 0.06 | n.s | −0.08 | n.s | −0.08 | n.s | 0.13 | 0.047 |
Conscientiousness | −0.05 | n.s | 0.06 | n.s | 0.20 | n.s | 0.00 | n.s | 0.02 | n.s | −0.03 | n.s |
MADRS, Montgomery–Asberg Depression Rating Scale; YMRS, Young Mania Rating Scale; NEO-FFI, NEO Five-Factor Inventory; STEP-GRP, Systematic Treatment Enhancement Program genetic repository; STEP-SCP, STEP standard care pathway; n.s., non-significant.
Regression coefficients (β) and p values reflect incremental change of one symptom point on personality factor scores.