Table 1.

State effects of MADRS depression and YMRS mania scores on NEO-FFI personality^a

	STEP-GRP						STEP-SCP
	Baseline		12 Months		24 Months		Baseline		12 Months		24 Month
	β	p	β	p	β	p	β	p	β	p	β	p
Depression
Neuroticism	0.16	<0.001	0.27	<0.001	0.38	<0.001	0.20	<0.001	0.25	<0.001	0.37	<0.001
Extraversion	−0.23	<0.001	−0.25	<0.001	−0.20	0.002	−0.22	<0.001	−0.27	<0.001	−0.28	<0.001
Openness	−0.09	0.02	−0.02	n.s	−0.11	0.04	−0.10	0.007	−0.09	n.s	−0.04	n.s
Agreeableness	−0.11	0.02	−0.07	n.s	−0.09	n.s	−0.09	0.03	−0.07	n.s	−0.24	<0.001
Conscientiousness	−0.15	0.004	−0.19	<0.001	−0.26	<0.001	−0.19	<0.001	−0.27	<0.001	−0.21	0.02
Mania
Neuroticism	0.14	n.s	−0.06	n.s	0.01	n.s	0.00	n.s	−0.06	n.s	−0.03	n.s
Extraversion	0.18	0.03	0.26	0.006	0.28	0.02	0.05	n.s	0.10	0.04	0.17	0.02
Openness	0.06	n.s	−0.05	n.s	0.10	n.s	0.05	n.s	0.07	n.s	0.17	0.01
Agreeableness	−0.19	0.02	−0.08	n.s	0.06	n.s	−0.08	n.s	−0.08	n.s	0.13	0.047
Conscientiousness	−0.05	n.s	0.06	n.s	0.20	n.s	0.00	n.s	0.02	n.s	−0.03	n.s

MADRS, Montgomery–Asberg Depression Rating Scale; YMRS, Young Mania Rating Scale; NEO-FFI, NEO Five-Factor Inventory; STEP-GRP, Systematic Treatment Enhancement Program genetic repository; STEP-SCP, STEP standard care pathway; n.s., non-significant.

^aRegression coefficients (β) and p values reflect incremental change of one symptom point on personality factor scores.