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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Neuropharmacology. 2023 Feb 9;228:109457. doi: 10.1016/j.neuropharm.2023.109457

Figure 3: Oprk1 mRNA expression and alcohol self-administration in TH::Cre rats following VTA viral infusions.

Figure 3:

Panel A: Oprk1 mRNA expression in VTA of male and female TH::Cre rats. Oprk1 mRNA expression in the VTA of both male and female rats was increased when exposed to the active AAV5-Ef1a-OPRK1-DIO-EYFP virus when compared to the control AAV5-Ef1a-DIO-EYFP virus (main effect of Viral Condition, **p < 0.01). Panel B: Alcohol self-administration (g/kg) in male and female transgenic TH::Cre rats. Alcohol self-administration levels following 28 days of viral incubation during the 5th and 6th week post-viral infusion demonstrated a significant increase (main effect of Viral Condition, **p < 0.01) in the active (AAV5-Ef1a-OPRK1-DIO-EYFP) viral infusion group when compared to the control (AAV5-Ef1a-DIO-EYFP). The negative control group (NC, misplaced active virus infusions outside the VTA) was included as a comparison.