Table 1: Twelve independent variants in 11 loci identified for association with eGFR-decline unadjusted and adjusted for eGFR-baseline.

We conducted GWAS for eGFR-decline baseline-unadjusted and baseline-adjusted (“decline”, n up to 343,339; decline_adj, n up to 320,737). This identified (A) 2 variants with genome-wide significance for eGFR-decline baseline-unadjusted (UMOD-PDILT, P_decline<5×10⁻⁸) and 2 further variants in a candidate search of the 263 variants known for cross-sectional eGFR¹⁵ outside UMOD-PDILT, judged at Bonferroni-corrected significance (P_decline<0.05/263=1.90×10⁻⁴; PRKAG2, SPATA7), (B) 5 variants with genome-wide significance for eGFR-decline baseline-adjusted AND Bonferroni-corrected significant baseline-unadjusted (P_{decline-adj-BL}<5×10⁻⁸, P_decline <0.05/12=4.17×10⁻³), (C) 3 variants with genome-wide significance for eGFR-decline baseline-adjusted but not significantly associated baseline-unadjusted (P_{decline-adj-BL}<5×10⁻⁸, P_decline≥4.17×10⁻³). For each identified variant, we show results for decline (baseline-unadjusted), for decline baseline-adjusted, and for cross-sectional eGFR¹⁵. Beta-estimates are in mL/min/1.73² per year and per faster-decline allele; significant P-values are stated in bold.

						decline		declineadj		cross-sectional
SNPID	Locus Name	Chr	Pos	EA/OA	EAF	Beta	P	Beta	P	Beta	P
A from GWAS/candidate search for decline (baseline-unadjusted)
rs34882080	UMOD-PDILT	16	20,361,441	a/g	0.815	0.065	2.45×10 −30	0.092	3.31×10 −62	−0.009	2.86×10 −95
rs77924615	UMOD-PDILT	16	20,392,332	g/a	0.798	0.074	5.30×10 −38	0.099	3.75×10 −69	−0.010	1.45×10 −138
rs10254101	PRKAG2 *	7	151,415,536	t/c	0.276	0.020	4.10×10 −05	0.037	1.78×10 −14	−0.007	1.85×10 −67
rs1028455	SPATA7 *	14	88,829,975	t/a	0.657	0.021	5.90×10 −06	0.024	3.43×10 −08	−0.002	4.78×10 −10
B from GWAS for declineadj, with association for decline (baseline-unadjusted)
rs1458038	FGF5	4	81,164,723	c/t	0.690	0.019	3.87×10 −05	0.028	6.85×10 −10	−0.003	7.49×10 −24
rs4930319	OVOL1	11	65,555,458	c/g	0.333	0.015	9.93×10 −04	0.028	5.27×10 −10	−0.003	2.21×10 −24
rs434215	TPPP §	5	699,046	a/g	0.277	0.020	3.70×10 −04	0.032	7.19×10 −09	−0.003	7.63×10−06
rs28857283	C15ORF54 †	15	39,224,711	g/a	0.656	0.021	1.47×10 −06	0.030	1.31×10 −11	−0.002	6.20×10 −09
rs13095391	ACVR2B	3	38,447,232	a/c	0.502	0.017	1.77×10 −04	0.025	4.03×10 −08	−0.003	6.57×10 −15
C from GWAS for declineadj, without association for decline (baseline-unadjusted)
rs9998485	SHROOM3	4	77,362,445	a/g	0.466	0.007	0.156	0.027	9.84×10 −09	−0.005	1.22×10 −41
rs1047891	CPS1	2	211,540,507	a/c	0.293	0.004	0.441	0.029	1.15×10 −09	−0.007	1.18×10 −75
rs2453533	GATM	15	45,641,225	a/c	0.422	0.002	0.710	0.029	1.72×10 −11	−0.009	4.57×10 −141

SNPID=Variant identifier on GRCh37, Locus name=Nearest Gene, Chr and Position=Chromosome and Position on GRCh37, EA/OA=Effect allele / other allele, EAF=effect allele frequency, beta and P=genetic effect coefficient of association and association P-value.

^*In PRKAG2 and SPATA7 loci, variants with smallest P_decline (rs73158188 and rs7160717, respectively) were highly correlated with these candidate-based variants (r²=1.00 and 0.93, respectively).

^§Since the TPPP locus lead variant had imputation quality <0.6 in 45% of the studies (median 0.64), we analyzed this locus omitting the imputation quality filter (with filter: decline_adj beta=0.033, P=1.00×10⁻⁸; decline beta=0.015, P=0.039; median imputation quality=0.74).

^†In the C15ORF54 locus, the identified lead variant for decline was highly correlated with a 2^nd signal lead variant for cross-sectional eGFR (rs28833881, r²=0.90), but not with the 1^st signal lead variant (rs12913015, r²=0.04).