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. Author manuscript; available in PMC: 2023 Mar 23.
Published in final edited form as: Kidney Int. 2022 Jun 16;102(3):624–639. doi: 10.1016/j.kint.2022.05.021

Table 3: The 9 variants’ effects on eGFR-decline unadjusted for eGFR-baseline in high-risk subgroups.

Shown are the 9 variants with genuine association for eGFR-decline for their association with eGFR-decline restricted to individuals with baseline diabetes mellitus (DM, n up to 38,206) or baseline CKD (i.e. eGFR<60 mL/min/1.73m2, n up to 26,653). Beta-estimates and 95% confidence intervals (CI) are in mL/min/1.73m2 per year and per faster-decline allele.

SNPID Locus Name Decline among DM at baseline
 Decline among CKD at baseline
 Decline among all
Beta 95% CI Beta 95% CI Beta 95% CI
A from GWAS/candidate search for decline (baseline-unadjusted)
rs34882080 UMOD-PDILT 0.159* 0.108, 0.211 0.138* 0.074, 0.203 0.065 0.054, 0.076
rs77924615 UMOD-PDILT 0.136* 0.084, 0.189 0.167* 0.099, 0.235 0.074 0.063, 0.085
rs10254101 PRKAG2 0.065 0.020, 0.110 0.095* 0.042, 0.148 0.020 0.010, 0.030
rs1028455 SPATA7 0.030 −0.011, 0.071 0.085* 0.034, 0.135 0.021 0.012, 0.029
B from GWAS for declineadj, with association for decline (baseline-unadjusted)
rs1458038 FGF5 0.030 −0.013, 0.072 0.040 −0.013, 0.092 0.019 0.010, 0.028
rs4930319 OVOL1 0.021 −0.021, 0.062 0.031 −0.019, 0.080 0.015 0.006, 0.024
rs434215 TPPP § 0.031 −0.024, 0.086 0.112* 0.043, 0.180 0.020 0.006, 0.035
rs28857283 C15ORF54 0.046 0.005, 0.086 0.042 −0.007, 0.091 0.021 0.013, 0.030
rs13095391 ACVR2B 0.029 −0.021, 0.080 0.006 −0.054, 0.066 0.017 0.008, 0.026
Average 0.061 0.079 0.030

SNPID=Variant identifier on GRCh37, Locus name=Nearest Gene, Beta=genetic effect of genetic association where the effect alleles is the same as in Table 1 and Table 2, 95% CI = 95% confidence interval of Beta (Beta±1.96*standard error of the association).

*

Statistically significant different from zero (P< 0.05/9=5.56×10−3).

§

Since the lead variant had imputation quality <0.6 in 45% of the studies (median 0.64), we analyzed this variant omitting the imputation quality filter (with filter: decline among DM at baseline beta=−0.093, P=0.338, n=927; decline among eGFR <60 mL/min/1.73m2 beta=0.022, P=0.618, n=2924; median imputation quality=0.74).