Fig. 6.

Knockdown of miR-4458 reversed the effect of circHMCU on BC cell invasion and migration. MDA-MB-231 and MCF-7 cells were transfected with si-NC, si-circHMCU, si-circHMCU + inhibitor NC, or si-circHMCU + miR-4458 inhibitor. A Cell invasion was tested by transwell assay. B-D Migration was examined by wound-healing assay. E The levels of MMP9 and MMP2 proteins were estimated by western blot. *P < 0.05