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. Author manuscript; available in PMC: 2023 Jun 10.
Published in final edited form as: Circ Res. 2022 Jun 9;130(12):1906–1925. doi: 10.1161/CIRCRESAHA.122.320257

Figure 3: SAUNA model of hypertension-associated HFpEF.

Figure 3:

The SAUNA model using a combination of SAlty drinking water, Unilateral Nephrectomy, and chronic Aldosterone to induce a model of hypertension-associated HFpEF in rodents. The schematic displays some of the key cardiac and extra-cardiac (e.g. chronic kidney disease) observed in this model. Recent mechanistic work in this model has implicated inflammation, endo-MT, and titin modifications as underlying pathogenic processes in the pathophysiology of hypertension-associated HFpEF. The illustration was made using images from smart.servier.com.