eTable 1. Overview of new and identified systematic reviews and GRADE tables.
Review on | Firstround? | Second round? | GRADE table? | No. of GRADE tables | Place of entry in expert material |
From: PIM Austria—project report | |||||
PPI | No | Yes | Second round | 1 | A02BC PPI |
Benzodiazepines | No | No | No | ||
● Comment: Irrelevant in second round due to lack of discrepancy between review and expert assessment | |||||
Alpha blockers | No | Yes | Second round | 1 | G04CA alpha-adrenoceptor antagonists |
● Comment: Not entered for individual substances | |||||
Ginkgo biloba | No | No | No | ||
● Comment: Irrelevant in second round due to lack of discrepancy between review and expert assessment | |||||
Anticholinergic urologics and beta-3-adrenoceptor agonists | No | No | No | ||
● Comment: Irrelevant in second round due to lack of discrepancy between review and expert assessment | |||||
Imidazoline receptor agonists | No | No | No | ||
● Comment: Irrelevant in second round due to lack of discrepancy between review and expert assessment | |||||
Tramadol | No | Yes | Second round | 1 | N02AX02 Tramadol |
Sulfonylureas | No | No | No | ||
● Comment: Irrelevant in second round due to lack of discrepancy between review and expert assessment | |||||
Z substances | No | No | No | ||
● Comment: Irrelevant in second round due to lack of discrepancy between review and expert assessment | |||||
Pregabalin | No | Yes | Second round | 1 | N03AX16 pregabalin |
Aldosterone antagonists | No | Yes | Second round | 1 | C03DA aldosterone antagonists |
● Comment: Not entered for individual substances being evaluated | |||||
From: generic review on aging | |||||
Anabolic steroids after hip fracture | Yes | No | First round | 1 | G03BA03 testosterone |
Second-generation antipsychotics: severe side effects | Yes | Yes | First round Second round |
1 | N05A antipsychotics |
Second-generation antipsychotics: mortality | |||||
● Comment: Not entered for individual substances being evaluated | |||||
Antibiotics in urinary tract infections | Yes | Yes | First round Second round |
1 | J01 antibiotics for systemic use |
● Comment: Not entered for individual substances being evaluated | |||||
Laxatives and iatrogenic falls | Yes | Yes | First round Second round |
1 | A06A medications to treat constipation |
● Comment: Not entered for individual substances being evaluated | |||||
Antihistamines and falls/fractures | Yes | Yes | First round Second round |
1 | R06A antihistamines for systemic use |
● Comment: Not entered for individual substances being evaluated | |||||
Atypical antipsychotics BPSD | Yes (risperidone) |
Yes (risperidone) |
First round Second round |
1 | N05AX08 risperidone |
Antidepressants in patients aged ≥ 65 years | Yes (duloxetine) |
Yes (duloxetine) |
First round Second round |
1 | N06AX21 duloxetine |
From: PRIMA-eDS and update/new research | |||||
DOAC | Yes (text form) |
No | No | B01AA vitamin-K antagonists | |
● Comment: Not entered for individual substances being evaluated | |||||
DPP-4 | Yes (text form) |
Yes | Second round | 2 | A10BH DPP-4 inhibitors |
● Comment: Two GRADE PDFs, one for each control | |||||
From: PRIMA-eDS | |||||
Beta-blockers | Yes | Yes | First round Second round |
2 | C07A beta-blockers |
● Comment: Not entered for individual substances being evaluated Two GRADE PDFs, one for each control | |||||
Metformin | Yes | No | First round | 5 | A10BA02 metformin |
● Comment: Five GRADE PDFs, one for each control | |||||
Total | 21 |
BPSD, Behavioral and psychological symptoms of dementia; DOAC, direct oral anticoagulants; DPP-4, dipeptidylpeptidase-4; PPI, proton pump inhibitors