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. 2022 Nov 30;2(11):1520–1531. doi: 10.1158/2767-9764.CRC-22-0175

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© 2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.

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Impact of lymphodepletion and alemtuzumab on UCART19 cellular kinetics. A, Total lymphocytes before and after (at the day of UCART19 infusion) lymphodepletion. B, Relationship between alemtuzumab total exposure and UCART19 expansion status. C, Positive correlation between alemtuzumab and UCART19 exposure. D, Correlation between UCART19 and IL7 C_max. E, Relationship between IL7 C_max and alemtuzumab doses. F, Relationship between IL7 C_max and UCART19 expansion status. Statistical comparison was performed using a Wilcoxon test for B, E, and F and a Spearman correlation for D.