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. 2022 Nov 30;2(11):1520–1531. doi: 10.1158/2767-9764.CRC-22-0175

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© 2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.

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Interplay between alemtuzumab, IL7, host immune system and UCART19 kinetics. Individual host T profiles up to day 60, highlighted by expansion status (A), relationship between alemtuzumab total exposure and host T early AUC (AUC_0-28; B), higher host T early exposures are correlated with the absence of observable UCART19 expansion (C), IL7 exposure AUC₂₈ and host T early exposure AUC_0-28 are strongly correlated (D). Individual host NK profiles up to day 60, highlighted by expansion status (E), relationship between alemtuzumab total exposure and host NK early AUC (AUC_0-28; F), absence of correlation between host NK early exposures and UCART19 expansion (G), absence of correlation between IL7 exposure AUC₂₈ and host NK early exposure AUC_0-28 (H). Statistical comparison was performed using a Wilcoxon test for C and G and a Spearman correlation for B, D, F, and H.