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. 2022 Nov 10;2(11):1404–1417. doi: 10.1158/2767-9764.CRC-22-0266

FIGURE 3.

FIGURE 3

ZL-1201 combination relies on the intact Fc domain on mAbs. Blockade of Fcγ receptors on macrophages limited in vitro phagocytosis of HCC1954 (A), FaDu (B), or Toledo (C) treated with isotype control (NT) or ZL-1201 (10 μg/mL) in combination with trastuzumab (A), cetuximab (B) or rituximab (C; 0.1 μg/mL). Treatment with F(ab’)2 of trastuzumab (D), cetuximab (E), or rituximab (F) does not enhance phagocytosis of HCC1954 (D), FaDu (E), or Toledo (F) cells in combination with ZL-1201. Data was shown as mean ± SD. *, P < 0.05; **, P < 0.01.