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. 2022 Nov 10;2(11):1404–1417. doi: 10.1158/2767-9764.CRC-22-0266

FIGURE 6.

FIGURE 6

ZL-1201 modulates intratumoral macrophages. Flow cytometry analysis showing percentage of M1 macrophages (A), M2 macrophages (B), and M2:M1 ratios (C) within infiltrating CD45+ immune cells in the indicated treatment groups in tumor samples collected at the end of efficacy study of SKOV3 xenograft model as shown in Fig. 5B. D and E, Flow plots showing M1 and M2 macrophages in one of five SKOV3 xenograft tumor tissues treated as shown. F, TNFα, MCSF, and IL4 production were measured by Luminex on SKOV3 tumor tissues 96 hours after paclitaxel or ZL-1201 treatment. G, TNFα was quantified in SKOV3 serum at 24 hours after isotype, ZL-1201, herceptin, or paclitaxel treatment. Data are shown as mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.